Science
Mechanism of Action
Derived from Substance P, PENTAPEPTIDE-26 has immunoregulatory properties that reduce inflammatory cytokines like IL-1α, IL-8, and TNF-α. This action helps to calm skin irritation and inflammation.
Research
Clinical Evidence
Medium confidence2%
Key findings
- 01 Clinical study on 32 healthy Asian female volunteers (29-60) showed 2% Capryloyl Pentapeptide-26 significantly decreased skin redness.
- 02 Clinical test on 16 volunteers (24-56) with severe dry, sensitive skin using a 2% formula greatly reduced TEWL and suppressed itching.
Transparency
Dusting Analysis
No data suggests PENTAPEPTIDE-26 is commonly used at ineffective concentrations or for 'dusting' purposes in formulations.
The Formula
Formulation
Safety
Safety Profile
No specific safety assessments from major regulatory bodies like CIR, SCCS, or FDA have been identified.
Your Skin
Skin Compatibility
Our Assessment
Verdict
PENTAPEPTIDE-26 is a valuable ingredient for sensitive and dry skin, showing promising clinical results in reducing inflammation and improving barrier function at 2%.
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References
Sources